隐球菌性脑膜炎临床特征分析

Analyses on clinical characteristics of cryptococcal meningitis

目的 :了解隐球菌性脑膜炎 (隐脑 )的临床特征 ,提高对隐脑的认识。方法 :对 5例隐脑临床特征进行回顾性分析。结果 :5例以头疼为首发症状 ,呈渐进型性加剧。脑脊液 (CSF)压力高于正常。其中≥ 4 0 0mmH2 O～ 6 0 0mmH2 O占 4 5 ;蛋白正常2例 ,轻度升高 <2g 3例 ;糖 5例均低于正常 ,其中 <1mmol L 4例 (4 5 ) ,氯化物 4例 94 9～ 10 7mmol L(4 5 )。结论 :头疼为首发症状 ,呈渐进型加剧是隐脑的重要表现 ,CSF压力≥ 4 0 0mmH2 O ,糖显著低于 1mmol L 。

Objective:To investigate the clinical characteristics of cryptococcal meningitis(CM),improve the recognization on CM.Methods:Five cases of CM were reviewed.Results:five CM patients had headache at the onset,presented progressive sign changes.CSF pressure elevated strinkingly.Of them 400～600mmH 2O were in 4 cases.CSF protein<2 0g/L in 5 cases.Glucose level of CSF in 5 cases were lower than 1mmol/L.Conclusion:This study shows that the most important clinical characteristics of CM were headache,not accompanied with fever at the onset,when initical CSF pressure strikingly elevated,glucose level were lower than 1mmol/L,CM should be considered.