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线粒体DNA ND-1基因点突变与2型糖尿病的关系 被引量：3

The association of ND-1 gene point mutations of mit ochondrial DNA with type 2 diabetes mellitus
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摘要 2型糖尿病患者中线粒体DNA(mtDNA) 331 6G→A、3394T→C突变频率分别为 3 .9% (6/1 52 )和 5 .3 % (8/ 1 52 ) ,显著高于正常对照者及冠心病患者。提示mtDNA 331 6G→A、3394T→G突变与 2型糖尿病相关。 In type 2 diabetic patients the f re quencies of point mutations 3316G→A and 3394T→C in mitochondrial DNA (mt DNA) were 3.9% (6/152) and 5.3% (8/152) respectively, which were significantly higher than those in normal controls and patients with coronary heart disease. This fi nding suggests that mtDNA 3316G→A and 3394T→G mutations are related to type 2 diabetes.
作者 钱杰 张丽容
机构地区 东南大学附属中大医院心内科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2003年第1期46-47,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 线粒体DNA 点突变 非胰岛素依赖型糖尿病 DNA, mitochondrial Point mutation Dia betes mellitus, non-insulin-dependent (Chin J Endocrinol Metab, 2003,19:46-47)
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

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同被引文献30

  • 1任慧珠.CDKALl基因和CDKN2A/2B基因与中国汉族人2型糖尿病的关系[D].天津医科大学,2009.
  • 2PERRY J R, FRAYLING T M. New gene variants alter type 2 diabetes risk predominantly through reduced beta- cell function [ J ]. Curt Opin Clin Nutr Metab Care, 2008, 11 (4) :371-377.
  • 3WU Y, LI H X, LOOS R J F, et al. Common variants in CDKAL1, CDKN2 A/B, IGF2 BP2, SLC30 A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population [ J ]. Diabetes,2008,57 ( 10 ) : 2834-2842.
  • 4LIN Y, LI P Q, CAI L, et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population [ J ]. BMC Med Genet,2010,11:97.
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  • 10陈静,万钢,冯洁,张建佚,相蕾,齐科研,孙亮,史晓红,唐雷,霍正浩,杨泽.2型糖尿病相关线粒体ND1基因的荟萃分析[J].中国心血管杂志,2009,14(4):304-306. 被引量：1

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中华内分泌代谢杂志
2003年 第1期

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