2型糖尿病肾病患者血清金属蛋白酶9及其组织抑制因子1水平变化的临床意义

Clinical significance of serum metalloproteinase mat rix-9 and its tissue inhibitor-1 in type 2 diabetic patients with nephropathy

测定 2型糖尿病肾病 (DN)患者和正常对照者血清基质金属蛋白酶 9(MMP 9) ,MMP组织抑制物 1 (TIMP 1 ) ,Ⅳ型胶原水平 ,以尿白蛋白排泄率判断DN严重程度。结果显示血清TIMP 1和Ⅳ型胶原水平随DN严重程度而明显升高 ,MMP 9呈降低趋势。TIMP 1、MMP

Serum metalloproteinase matrix (M MP )-9, tissue inhibitor of metalloproteinase (TIMP)-1 and type Ⅳ collagen level s were measured in patients with diabetic nephropathy (DN). The severity of DN w as determined by urinary albumin excretion rate. The results show that signific ant increases of serum TIMP-1 and type Ⅳ collagen depend on severity of DN, wh ile MMP-9 tends to decline. TIMP-1 and MMP-9 seem to participate in the patha genesis of DN.