大鼠“泻剂结肠”模型的动力学研究

Study of the motility of rat model of cathartic colon

目的 探讨慢传输性便秘 (slowtransitcomstipation ,STC)的发生发展机制及与接触性泻剂的关系。方法 以临床上常用的接触性泻剂大黄建立大鼠“泻剂结肠”模性 ,应用传输试验的肌条收缩反应试验对大鼠结肠动力及对已酰胆碱反应性进行了检测。结果 (1)大鼠饲以大黄 3个月后 ,肠道传输明显减慢。 (2 )“泻剂结肠”大鼠对已酰胆碱反应性明显降低。结论 (1)长期服用接触性泻剂 ,可至结肠动力减弱。 (2 )STC的发病与平滑肌及壁内神经病变有关 。

Objective To investgate the motility and cause of slow transit constipation(STC).Methods An experimental rat model of STC was reconstructed by contract laxatives mixed with the feed.The motility of cathartic colon was studied by activated charcoal suspension pushing test,muscle strips test.Results The results were as following:1.colon transit time of the rats delayed significantly after treating with rhubarb for 3months.2.the reaction to acetycholine(Ach)decreased in the cathartic colon.Conclusion The results indicate that chronic application of stimulant laxatives can induce disorganization of dynamic and injure enteric nervous system.The alteration of Ach receptors may be one of many factors involved in STC.