循证医学方法评价干扰素治疗尖锐湿疣

Evaluating the efficacy of interferon for condyloma acuminatum with EBM method

目的:对干扰素(IFN)治疗尖锐湿疣的给药途径、剂量、治疗效果进行评价。方法:应用循证医学的方法,对IFN治疗尖锐湿疣的文献进行系统分析,借助治疗组有效率、相对效益度、需要治疗的人数、相对效益增加率和绝对效益增加率等指标,对16篇相关文献的系统分析。结果:分析认为皮损基底部注射IFN是治疗尖锐湿疣较好的方法。结论:IFN-α和IFN-β在尖锐湿疣的治疗效果无明显差异。

Objective:To evaluate the therapeutic effect of IFN with different methods of administration,doses,subtypes of in-terferon on condyloma acuminatum.Methods:Seventeen clinical trial reports on the treatment of condyloma acuminatum were re viewed systematically with evidence based medicine method and the efficacy rate,relative benefit,the number of patients need to be treated,the increased rates of relative benefit and absolute benefit were evaluated.Results:The intralesional injection of INF was more effective than other methods of administration.Conclusions:There was no significant difference in the treatment of condyloma acuminatum between IFN-αand IFN-β.