氯代5-氟脲嘧啶卟啉的红外光谱特性的研究

FTIR Studies of Chlorobenly-5-fluorouracil Porphyrin

本文对新合成的对位及间位两类氯代苯基 5 氟脲嘧啶卟啉的红外光谱吸收峰进行了归属和总结 ,讨论了其红外吸收频率随取代基位置变化的规律。指出了苯环上的取代基为电负性强的基团时 ,由于场效应的存在 ,使被测化合物的羰基伸缩振动吸收峰的相对强度发生改变。同时 ,表明了嘧啶环上N原子发生了取代 ,形成单、双取代 5 氟脲嘧啶卟啉化合物的红外光谱特性。

In this paper new kind of porphyrin compounds was prepared, which combined well the affinity of prophyrin to malignant tumour with anticancer of 5-fluorouracil porphyrin. The IR spectra of m- and p-cNorophenyl-5-fluorouracil prophyrin were obtained and analyzed. The IR absorption peaks were investigated and concluded in detail. The IR absorption rule of chloropenly-5-fluorouracil prophyrin which occurred when m-substitution and p-substitution appeared respectively on phenyl, and single substitution of N-1 and double substitution of N-1 appeared respectively on phenyl or N-1 and N-1, N-3 positions on pyrimidine ring was also discussed. The results show that the relative intensity of nu(o=o) stretching vibration changed obviously by field-effect when the substitution was strong electronegative group. Meanwhile, the IR spectral characteristics of the compounds mentioned above were revealed, and this can be used to deduce the stereochemistry structure of them.