摘要
利用紫杉醇分子中 2′ 羟基较高的反应活性 ,将紫杉醇连接到经氨基酸修饰后的水溶性聚乙二醇 (PEG)分子上 ,制得了新型紫杉醇给药系统 (DDS) ,测定了DDS的水溶性、紫杉醇含量及体外抗肿瘤活性 .研究表明 ,此类系统水溶性良好 (达紫杉醇的 2 0 0～ 40 0倍 ) ,对乳腺癌MCF 7细胞和非小细胞肺癌PG细胞有很强的抑制作用 ,效果与紫杉醇相当 。
A novel drug delivery system (DDS) of taxol was developed by linking taxol to a water-soluble polymer-polyethylene glycol (PEG) through amino acid spacer. Solubility of the DDS and content of taxol in them were determined. Their antitumor activity were evaluated against two human tumor cell lines; MCF-7 and PG. It was found that the DDS were more soluble in water than taxol and had similar cytotoxicity compared with the latter. In this way, a new kind of DDS of taxol with improved water-solubility and potential antitumor activity was well established.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2003年第2期209-214,共6页
CIESC Journal
基金
天津市导向性重大攻关项目 (No 983111811)
