3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮及1-(1H-1,2,4-三唑-1-基)取代苯乙酮与二溴化物的关环反应及产物的生物活性

Cyclization Reactions of 3,3-Dimethyl-1-(1H-1,2,4-triazolo-1-yl)-2- butanone or Substituted 1-(1H-1,2,4-Triazolo-1-yl)acetophenone with Dibromide Compounds and Its Biological Activities

通过二溴化物与唑酮 1 [R=(CH3) 3C]或α-三唑基苯乙酮 1 (R=Ar)的亲核取代反应 ,合成了新型的环状三唑类化合物 3和 4 ,经元素分析 ,1H NMR,IR,EI-MS和 X射线衍射等方法确证其结构 ,讨论了反应过程 .生物活性测试发现大部分化合物具有很好的杀菌活性 。

The title compounds 3 and 4 were prepared by nucleophilic substitution reaction of compounds 1 with dibromide 2. Their structures were determined by elementary analysis, 1H NMR, IR, EI-MS and X-ray diffraction method. The reaction procedure was also studied in detail. From the screening results of biological activities, most compounds possess good fungicidal activities, especially against Puccinia recondita.