摘要
用化学合成及后处理工艺制得多孔羟基磷灰石生物材料。X射线衍射、红外光谱分析证实 ,合成产物晶型单一、纯度高 ;扫描电镜 (SEM)观测表明 ,HA呈球形、均匀分布在 40 0～ 70 0 μm之间 ,并具有利于新骨生长的连通性孔道。实验测得n(Ca) /n(P)约为 1 67,与人骨组成相似 ,表明其生物活性高。同时以牛血清白蛋白为模型药物 ,探讨了聚乳酸 (PLA)包覆多孔羟基磷灰石材料作为药物缓释载体材料的可能性 。
A porous spherical hydroxyapatite(HA) ceramic biomaterial has been prepared dire ctly by a simple chemical synthetic method followed by treatment with chitosan solution and calcination. The synthesized HA material of high purity consisted of a unique normal HA structure as confirmed by XRD and IR measurements.The size of fine spherical HA with most inner ducts linked up to each other for fresh bone to develop was well distributed between 400～700 μm by SEM obser vation. The mass ratio of Ca and P was about 1 67, close to that in human bone. The porous HA coated by polyactic acid(PLA) has been explored for drug delivery material using serum albumin as a model protein. A good result was obtained.
出处
《应用化学》
CAS
CSCD
北大核心
2003年第3期223-227,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助课题 ( 70 0 710 4 8
2 97770 30 )
