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生物可降解聚乙二醇-b-聚对苯二甲酸丁二醇酯共聚物载药微球的制备 被引量:3

Preparation of Biodegradable Levonorgestrel Encapsulated Poly(ethyleneglycol)-b-Poly (butyleneterephthalate) Microspheres
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摘要 The behavior of poly(ethylene glycol)-b-poly(butylene terephthalate) copol ymer has been investigated. The influences of the immersing time(in phosphate buffer solution of pH=7 4, at (37±1) ℃) on the sw elling ratio, the mass loss and the surface morphology of the copolymer film were examined. The copolymer is found to be degradable. The m icrospheres of PEG-b-PBT were prepared by a solvent extraction method using PVA as a stabilizer and characteristic of a sm ooth and spherical surface, sized about 1 133 μm. IR and XRD results reveal that Levonorgestrel crystalls are physically entrapped in the microspheres of the copolymer. The behavior of poly(ethylene glycol)-b-poly(butylene terephthalate) copol ymer has been investigated. The influences of the immersing time(in phosphate buffer solution of pH=7 4, at (37±1) ℃) on the sw elling ratio, the mass loss and the surface morphology of the copolymer film were examined. The copolymer is found to be degradable. The m icrospheres of PEG-b-PBT were prepared by a solvent extraction method using PVA as a stabilizer and characteristic of a sm ooth and spherical surface, sized about 1 133 μm. IR and XRD results reveal that Levonorgestrel crystalls are physically entrapped in the microspheres of the copolymer.
出处 《应用化学》 CAS CSCD 北大核心 2003年第3期293-295,共3页 Chinese Journal of Applied Chemistry
基金 国家"八六三"计划 ( 2 0 0 1AA2 16 0 77)资助项目
关键词 生物可降解性 聚乙二醇 聚对苯二甲酸 聚对苯二甲酸丁二醇酯 载药微球 制备 左炔诺孕酮 PEG-b-PBT嵌段共聚物 poly(ethylene glycol)-b-poly(butylene terephthalate) copolymer,biodegradab ility,Levonorgestrel
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参考文献1

  • 1张勇 张爱英 冯增国.Acta Polym Sin(高分子学报)[J],2002,(2):167-167.

同被引文献50

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