干燥综合征合并肾小管性酸中毒临床分析

The clinical analysis of Sjgren's syndrome accompanied by renal tubular acidosis

目的 结合临床、实验室及氯化铵试验 ,进一步了解干燥综合征 (SS)合并肾小管性酸中毒(RTA)的发生情况。方法 对我院 1993年 6月～ 1999年 12月收治SS患者 75例 ,常规进行免疫学、口唇活检、角膜染色、3h尿白细胞计数及氯化铵试验等检查。结果 45 75为远端肾小管性酸中毒 (dRTA) ,13 45为完全型 ,41 45为不完全型。 15 45合并其它自身免疫性疾病 ,13 45伴低血钾麻痹 ,36 45 (83 % )泌尿系感染。结论 SS合并dRTA十分常见 ,对SS患者应常规作氯化铵试验。抗泌尿系感染可减少肾小管及间质的损害 ,改善肾功能。

Objective To study further the occurrence of sjgren's syndrome(SS) accompanied by renal tubular acidosis(RTA) by analysis of clinical and laboratory data and NH 4Cl test.Methods From 1993.6 to 1999.12,75 hospitalized patients of SS were investigated,The routine measures,including immunologic examination,biopsy of lip,stain of cornea,3 hours urine leucocyte count and NH 4Cl load test were performed.Results 45/75 showed distal RTA(dRTA),furthermore,13/45 were complete type,32/45 were uncomplete type.15/45 were accompanied by other immune diseases.13/45 were accompanied by hypokalemia paralysis,and 83%(36/45) by the urinary infection.Conclusion SS with dRTA is frequently seen clinically.It is necessary to perform NH 4Cl load test in patients with SS.The treatment of urinary tract infection may decrease the renal tubular and interstitial damage and improve the function.