2-巯基-5-甲氧基-1H-苯并咪唑的合成工艺改进

A New Synthetic Method of 2-mercapto-5-Methoxy-1H-enzimidazole

以扑热息痛为原料,经甲基化、硝化、水解得到2 硝基 4 甲氧基苯胺,以水合肼还原后,再与乙基黄原酸钾环缩合得2 巯基 5 甲氧基 1H 苯并咪唑,总收率达66 7%.

Paracemol was methylated, nitrified and hydrolyzed to give N(2nitro4methoxy)phenyldiamine which was reducted then in the presence of hydrazine hydrate. 5Methoxy2benzimidazolethiol was synthesized via cyclocondensation reaction of 4methoxy1,2benzenedoamine with potassium ethyl xanthate in the overall yield of 667%.