生脉散对急性病毒性心肌炎临床症状及炎性损伤指标的影响

Effect of Sheng Mai San on the Symptoms and the Markers of Inflammatory Damage in Patients with Acute Viral Myocarditis

目的 :观察生脉散治疗急性病毒性心肌炎的客观疗效。方法 :将 10 2例急性病毒性心肌炎随机分为生脉组和对照组 ,其中生脉组 5 2例 ,对照组 5 0例。采用半定量积分法观察两组治疗前及治疗 4周后病人胸闷、心悸、胸痛改善情况 ,同时检测治疗前后心电图 (EKG)、2 4h动态心电图(Holter)、中和抗体、cTnI、cTnT的改变情况。结果 :生脉组在胸闷改善方面与对照组有统计学意义 (P <0 .0 1) ,两组在心悸、胸痛、心电图 (EKG )及 2 4h动态心电图 (Holter)方面也有统计学意义 (P <0 .0 5 ) ,cTnI、cTnT转阴率两组分别为 5 9%与 3 2 %、72 %与 43 % ,有统计学意义 (P <0 .0 5 ) ,中和抗体则无统计学意义 (P >0 .0 5 )。结论 :生脉散对急性病毒性心肌炎改善临床症状和炎性损伤指标修复有较好的作用。

Objective:To evaluate the efficacy of Sheng Mai San(SMS) on acute viral myocarditis.Methods:102 patients with acute viral myocarditis were randomized to guoup SMS(n=52)and placebo group(n=50).Semiquantitative integral methods were taken to observe changes of clinical symptoms such as dyspnea,palpitation and chest pain after 4 weeks of treatment,simultaneously EKG,24Holter,concentration of serum cardiac troponin-I,cardiac troponin T and neutralizing antibody test to the coxsackie B virus were measured.Results:Dyspnea was improved much more marked in SMS group than in placebo group(P<0.01).Palpitation,chest pain,the abormality of EKG and Holter were also improved significantly in SMS group than in placebo group(P<0.05),the negative rate of cTnI and cTnT were 59% vs 32% and 72% vs 43% respectively in the SMS group and placebo group(P<0.05).Conclusion:The SMS has comparatively good effect on the clinical symptoms and inflammatory injury markers of acute viral myocardits.