针刺对快速老化痴呆小白鼠脑组织CA神经递质的影响

Influence of Acupuncture on Catecholamine Neurotransmitter in Brain Tissues of SAMP8

目的 探讨针刺治疗痴呆的中枢作用机制。方法 采用快速老化痴呆小白鼠 ( SAMP8)为模型 ,以补肾、健脾针刺法作为处理因素 ,用高效液相色谱 -电化学检测法测脑组织儿茶酚胺类 ( CA)神经递质。结果和结论 10月龄 SAMP8较正常老化小白鼠 ( SA MR1)脑组织 CA神经递质降低 ;补肾针法对于改善痴呆和升高降低的 CA神经递质的作用优于健脾针法。

Objective To explore the central mechanism of acupuncture in the treatment of dementia. Methods The senescence accelerated mice (SAMP8) were modeled to be with dementia and treated by acupuncture by nourishing the kidneys and spleen; the catecholamine neurotransmitter in the brain tissues were assayed with high performance liquid chromatography and electrochemical measurement. Results and Conclusion The catecholamine neurotransmitter in the brain tissues was less in 10-month-old SAMP8 than in SAMR1; kidney-nourishing acupuncture is better than spleen-nourishing acupuncture in improve dementia and elevating catecholamine neurotransmitter. It is indicated that acupoints have some special features.