针刺对妊娠末期大鼠的促宫缩作用

Mechanism of Acupuncture in Promoting Uterine Contraction in Late Pregnancy Rats

目的 探讨针刺促宫缩作用的机理。方法 将妊娠末期大鼠随机分为空白组、蓖麻油组、针刺组、临产组 ,用放免法测定羊水雌二醇 ( E2 )、孕激素 ( P)、羊膜前列腺素 E2 ( PGE2 )、血浆内皮素 ( ET)、血清—氧化氮 ( NO )。结果 针刺可明显提高雌激素 /孕激素比值 ,增加内皮素、一氧化氮、前列腺素 E2 含量 ,但不改变内皮素 /一氧化氮比值。结论 针刺促宫缩作用的途径可能与改变各宫缩物质的含量或比例有关 。

Objective To observe the mechanism of acupuncture in promoting uterine contraction. Methods Rats with late pregnancy were randomized into control group, castor-oil group, acupuncture group and labor group. Radioimmunoassay was used to detect estrogen (E 2), progesterone (P), protaglandin E 2 (PGE 2), endothelin (ET) and nitirc oxide (NO). Results Acupuncture can increase E/P, ET, NO and PGE 2, but does not alter ET/NO. Conclusion Acupuncture may change the substances in relation to uterine contraction, and eventually promote labor.