果糖二磷酸钠镁对大鼠脑出血的保护作用

Protective effects of sodium magnesium fructose diphosphate on intracerebral hemorrhage

目的 :研究果糖二磷酸钠镁 (FDPM )对脑出血的保护作用。方法 :以胶原酶尾状核注射诱导大鼠脑出血模型 ,观察FDPM对大鼠脑出血后神经病学评分、脑含水量、血脑屏障通透性及脑组织病理改变的影响。结果 :FDPM 4 0 0mg·kg-1可降低脑出血大鼠神经病学评分 ,降低脑组织含水量 ,改善血脑屏障通透性 ,减轻脑组织病理改变 ,其作用强于相似剂量的 1,6 二磷酸果糖或硫酸镁 ,而FDPM 133mg·kg-1没有明显作用。结论 :FDPM对脑出血有显著的保护和治疗作用 ,其作用强于相似剂量的 1,6 二磷酸果糖或硫酸镁。

Objective:To study the protective effects of sodium magnesium fructose diphosphate(FDPM) on intracerebral hemorrhage(ICH). Methods :ICH was induced in adult rats by stereotaxical injection of bacterial collagenase into left caudate nucleus, and the effects of FDPM on neural scale, water content of brain,permeation of blood-brain barrier(BBB) and histopathological change of rat brain subjected to ICH were observed. Results :FDPM(400mg·kg -1 ) was more potent than similar dose of fructose-1,6-diphosphate(FDP) or MgSO_4 to reduce the neural scales,decrease water content,improve peamination of BBB and relieve pathological change of rat brain subjected to ICH,but 133mg·kg -1 FDPM had no effects. Conclusion :FDPM may prevent brain tissue from ICH damage,its effects are more potent than that of similar dose of FDP or MgSO_4.