急性脑梗死患者血清性激素水平及凝血指标的观察

The observation of sex hormone and blood clotting parameters in patients with acute cerebral infarction

目的 探讨急性脑梗死 (ACI)患者血清性激素水平及凝血指标的变化。方法 应用酶联免疫吸附法、比色法、比浊法检测 116例老年ACI患者的血清雌二醇 (E2 )、睾酮 (Te)、E2 /Te、抗凝血酶 Ⅲ (AT Ⅲ )及纤维蛋白原 (FIB)的含量变化 ,并与 78例健康者作对照。结果 ACI组男性患者血清E2 、E2 /Te、FIB含量较对照组明显升高 (P <0 .0 1,P <0 .0 5 ,P <0 .0 5 ) ,而Te、AT Ⅲ含量较对照组降低 (均P <0 .0 5 ) ;ACI组女性患者血清E2 、Te、AT Ⅲ含量较对照组低 (P <0 .0 1,P <0 .0 5 ,P <0 .0 5 ) ,其中以E2 降低更为明显 ,而E2 /Te无显著性差异 (P >0 .0 5 )。FIB含量较对照组明显升高 (P <0 .0 5 )。结论 不同性别ACI患者存在不同性激素失衡 。

Objective To investigate the level of sex hormone in serum and blood clotting parameters in patients with acute cerebral infarction(ACI).Methods The level of estradiol(E 2),testosterone(Te),E 2/Te,antithrombin Ⅲ(AT Ⅲ) and fibrinogen(FIB) in the serum of 116 old patients with ACI and 78 healthy subjects were measured by ELISA, Enzyme colorimetric method.Results The concentration of E 2? E 2/Te?FIB in the male patients with ACI were higher than that of control group ( P <0.01, P <0.05, P <0.05). The concentration of Te, AT Ⅲ were lower than the control group ( P <0.05).The concentration of E 2?Te?AT Ⅲ in the female patients with ACI were lower than that of control group( P <0.01, P <0.05, P <0.05). Especially E 2 was significantly decreased, but E 2/Te did not show any obvious difference( P >0.05). The concentration of FBI was higher than that of control group( P <0.05).Conclusion The disorder of the sex hormone is one of the risk factors in different sex patients with ACI.