伊贝沙坦对慢性肾小球肾炎患者血压和尿蛋白排泄的影响

Influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis

目的 :观察伊贝沙坦对慢性肾小球肾炎患者的血压、尿蛋白排泄的影响。方法 :2 7例慢性肾小球肾炎患者应用伊贝沙坦治疗 8wk ,观察治疗前后血压、尿蛋白、肾功能、血钾、肝功能和血脂的变化。结果 :与伊贝沙坦治疗前相比 ,治疗后血压、2 4h尿蛋白定量显著下降 ,对肾功能、血钾、肝功能和血脂无影响。结论 :伊贝沙坦对慢性肾小球肾炎患者具有平稳显著的降压、降蛋白尿作用 ,继而发挥肾保护作用。

AIM: To investigate the influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis. METHODS: 27 patients with chronic glomerulonephritis were treated with irbesartan for 8 wk. Blood pressure, proteinuria, renal function, serum K+, liver function, and serum lipid were detected before and after 8 wk. RESULTS: The levels of blood pressure and 24 h proteinuria were decreased significantly (P< 0.01) 8 wk after the administration, but the renal function, serum K+, liver function and serum lipid were unchanged. CONCLUSION: Irbesartan shows a stable anti-hypertensive effect and can reduce proteinuria in patients with chronic glomerulonephritis.