临界高血压患者经卡托普利治疗前后血管内皮功能的超声对比研究

Effect of captopril on vascular endothelium function in patients with essential boundary hypertension by high-frequence ultrasound

目的 :研究卡托普利对临界原发性高血压患者血管内皮功能的影响。方法 :利用高分辨超声技术 ,观察了 2 3例临界原发性高血压患者和 2 0例正常人的肱动脉血管内皮依赖性舒张功能。结果 :虽然两组受检者对硝酸甘油的反应性无显著性差异(% :2 6.0 2± 5 .5 9vs 2 8.0 2± 6.0 4 ,P >0 .0 5 ) ,但临界高血压患者肱动脉血流介导性较正常组明显减弱(% :6.34± 2 .4 3vs 2 4 .38± 5 .87,P <0 .0 5 )。经服用卡托普利治疗血压控制 3mon后 ,肱动脉内皮性舒张较治疗前明显改善 (% :2 2 .5 0± 5 .4 5vs 6.34±2 .4 3,P <0 .0 5 ) ,且基本恢复至正常。结论 :临界高血压患者存在血管内皮依赖性舒张功能障碍 ,经卡托普利治疗后 ,受损的血管内皮依赖性舒张功能能恢复致正常水平。

AIM: To study the impact of Captopril on vascular endothelium function in patients with essential boundary hypertension. METHODS: We examined the endothelium-dependent vasodilation of brachial arteries in 23 patients and 20 normal subjects by high-frequence Ultrasound. Results: Though there were not significantly differences in vasodilation of brachial arteries during given Nitroglycerin between two groups(%: 26.02± 5.59 vs 28.02± 6.04,P> 0.05), the change of dimater of brachial arteries during reactive hyperaemia decreased remarkably in patients in contrast to the normal. The change became normal after patients having taken Captopril for three months (%: 22.50± 5.45 vs 6.34± 2.43,P< 0.05). CONCLUSION: There was some decrease of vascular endothelium function in patients with essential boundary hypertension. But the injured endothelium function could recover after given Captopril.