双氢麦角碱治疗椎-基底动脉供血不足

Dihydroergotoxine in treating vertebrobasilar insufficiency

目的 :观察双氢麦角碱治疗椎 基底动脉供血不足的疗效。方法 ;双氢麦角碱组 30例 ,男性 19例 ,女性 11例 ,年龄 (60 .0±s 2 .7)a ,给双氢麦角碱0 .6mg加入氯化钠注射液 5 0 0mL静脉滴注 ,qd ,共7d。丹参组 2 5例 ,男性 17例 ,女性 8例 ,年龄 (61± 3)a ,给丹参 2 0mL加入低分子右旋糖酐 5 0 0mL静脉滴注 ,qd ,共 7d。观察临床疗效和椎 基底动脉血流变化。结果 :双氢麦角碱组有效率 83% ,丹参组有效率 36% ,2组疗效比较差异有非常显著意义(P <0 .0 1) ,双氢麦角碱组椎 基底动脉血流明显改善 ,与丹参组比较 ,差异有非常显著意义 (P <0 .0 1)。结论 :双氢麦角碱能迅速有效控制椎

AIM: To observe the effect of dihydroergotoxinem in treating vertebrobasilar insufficiency. METHODS: Thirty patients(M 19,F 11;age( 60.0 ± s 2.7)a) of dihydroergotoxine group were treated with dihydroergotoxine 0.6 mg +0.9% sodium chloride injection 500 mL,iv,gtt,qd×7 d. Twenty five patients(M 17,F 8;age(61±3)a) of salvia miltiorrhiza group were treated with salvia miltiorrhiza injection 20 mL and low molecular dextran 500 mL iv,gtt,qd×7 d.The clinical effect and the vertebrobasilar blood flow were observed. RESULTS: The effective rate of dihydroergotoxine group was 83 % and that of salvia miltiorrhiza group was 36% ( P<0.01 ). Vertebrobasilar blood flow of dihydroergotoxine group raised greatly compared with that of salvia miltiorrhiza group ( P< 0.01 ). CONCLUSION: Dihydroergotoxine can rapidly and effectively control vertebrobasilar insufficiency.