银杏内酯对腺嘌呤致肾功能不全的保护作用研究

Protective effect of ginkgolide on renal failure induced by adenine

目的 :实验观察银杏内酯对腺嘌吟所致大鼠肾损害的影响。方法 :用腺嘌呤建立大鼠肾功能不全模型 ,测定血中尿素氮 (BUN)、肌酐 (Crea)、胆固醇 (CH)、总蛋白 (TP)、白蛋白 (ALP)及病理变化。结果 :银杏内酯对腺嘌呤造成的慢性肾功能不全有一定疗效 ,低、中剂量可显著降低BUN、Crea的升高 ,低剂组还可显著降低CH的升高。结论

Objective: To study the protective effect of ginkgolide on rat's renal failure induced by adenine.Methods: The chronic renal functional failure model of rat was established with adenine. Its urea nitrogen (BUN), reatinine (Crea), Cholesterin (CH), total protein (TP), and albumin (ALP) in blood were determined. The pathologic changes were also observed. Results: Ginkgolide has effects on renal failure caused by adenine. Low and high dose groups decrease BUN. Crea, low dose group decrese CH, high dose group increase numbers of kindney glomerulus.Conclusion: Ginkgolide has protective effect on rat's renal failure induced by adenine.