化疗后24小时与血液学毒性增至Ⅱ度以上时皮下注射rhG-CSF的疗效对比

rhG-CSF Administration Starting in 24hs After Chemotherapy or when Haematological Toxicity Occurs:A Comparative Study

目的 分析基因重组人粒细胞集落刺激因子 (rhG -CSF)在化疗后 2 4h与血液学毒性降至Ⅱ度以下时开始给药的临床疗效。方法 采用随机分组法 ,将 160例患者随机分成A组和B组。A组 :化疗后 2 4h即刻皮下注射rhG -CSF、连续 3天 ;B组 :血液学毒性增至Ⅱ度以上时皮下注射rhG -CSF连续 3天。结果 A组与B组比较 ,A组白细胞 (WBC)及中性粒细胞 (ANC)下降程度低 ,持续时间短 ,化疗延迟率较低 ,化疗延迟时间较短 ,2组不良反应相比较无显著性差异 (P >0 .0 5 )。结论 化疗 2 4h后给药可减轻化疗所致WBC及ANC下降的程度及缩短其持续时间 ,保证下

Objective To study the clinical effective of rhG CSF administrated in 24hs after chemotherapy or when heamatological toxicity occurs.Methods A randomized single blind clinical trial was conducted.160 patients were enrolled into group A and B.In group A,rhG CSF was given 75 ug a day s.c. starting in 24hs after chemotherapy for 3 days,and in group B,rhG CSF starting only when heamatological toxicity degree Ⅱ occured.Results In group A,WBC and ANC decreased slowly and maintained shortly,chemotherapy delayed rate and delayed time were shorter.There was no significant difference in side effect between the two groups( P >0.05).Conclusion It can alleviate WBC and ANC decrease degree and shorten the continued time and guarantee next chemotherapy cycle to go on smoothly when G CSF is given in 24hs after chemotherapy.