介入化疗栓塞治疗宫颈癌的临床应用

Clinical Application of Interventional Chemotherapy and Embolization to Treat Cervical Carcinoma

目的 评价经子宫动脉介入灌注化疗栓塞对宫颈癌的疗效及并发症。方法 对 46例宫颈癌患者采用Seldinger技术 ,经右侧股动脉穿刺并分别插管至左、右子宫动脉行灌注化疗或栓塞。其中 ,19例行单侧子宫动脉栓塞 ,2例行双侧子宫动脉栓塞。介入治疗后 ,2 8例行根治术。结果 介入治疗后症状缓解率为 10 0 .0 %。 6例患者肿瘤大出血得以控制。 2 8例手术患者中可观察到肿块体积明显缩小 ,总有效率为 97.4%。栓塞后 3例出现栓塞侧附件缺血、坏死 ,2例出现输尿管运动障碍及 2例出现臀部瘀血、坏死等并发症。结论 经子宫动脉介入灌注化疗栓塞对宫颈癌患者有非常满意的近期疗效。

Objective To evaluate the effectiveness and complication of uterine arerial chemotherapy and embolization for treatmet of cervical carcinoma.Methods 46 patients with pathologically confirmed cervical carcinoma were treated with interventiond therapy.The age of the patients ranged between 24～65 years.The Seldinger′s technique was used in all patients.The combined antineoplastic agents were infused into the contralateral and ipsilateral uterine arterial.Among them,the contralateral uterine arteries in 19 cases and bilateral uterine arteries in 2 cases were embolized.After interventional treatment,radical uterotomy were performed in 28 patients.Results The relative clinical symptoms were significantly released in all patients.The obviously curative effect for stanch bleeding was shown in 6 patients.The size of tumor was decreased in all patients.The effective rate was 97.4%.But uterine arteries embolization may cause severe complications.For example:the ovariotuble bloodless,necrosed,pelvic edema ect.Conclusion The interventional chemotherapy is very effective to treat cervical carcinoma.