纳络酮加脑活素治疗新生儿缺氧缺血性脑病

Observation of Therapeutic Efficacy of Naloxone Plus Cerebrolysin in Neonatal Hypoxic Ischemic Encephalopathy

目的 :观察纳络酮加脑活素治疗新生儿缺氧缺血性脑病 (HIE)的临床疗效。方法 :将本院出生的 10 3例HIE新生儿随机分为治疗组 5 2例 ,对照组 5 1例。对照组在综合治疗的基础上加用脑活素治疗。治疗组在对照组的基础上再给予纳络酮 ,两组脑活素用法均为 5ml加入 10 %葡萄糖 5 0ml,静脉滴注 ,1次 /d ,疗程 14d ;治疗组纳络酮0 .1mg/kg·d-1,加入 10 %葡萄糖 5 0ml,静脉滴注 ,疗程 7d ;观察近期疗效。结果 :治疗组显效 2 9例 ,有效 2 0例 ,无效 3例 (其中死亡 1例 ,放弃治疗 2例 ) ,有效率 94 % ;对照组显效 2 2例 ,有效 16例 ,无效 13例 (其中死亡 4例 ,放弃治疗 9例 ) ,有效率 74 % ,两组总有效率相比差异有高度显著性 (χ2 =7.6 6 ,P <0 .0 1)。结论

Objective: To observe the therapeutic efficacy of naloxone and cerebrolysin in neonatal hypoxic ischemic encephalopathy (HIE). Methods:One hundred and three neonates with HIE were randomly divided into two groups: Fifte two cases in treatment group who were treated with naloxone( 0.1 mg/kg·d -1 ) and cerebrolysin(5 ml/d) and other 51 cases in control group who were treated with cerebrolysin(5 ml/d) alone.Results:The therapeutic effectve rate in the treatment group was 94%,while that in the control group was 74%.There was significant difference between the two groups,χ 2=7.66, P <0.01.Conclusion:It's more effective to treat neonatal HIE with naloxone plus cerebrolysin than with cerebrolysin alone.