甲壳低聚糖对糖尿病NOD小鼠的治疗作用

Chitooligosaccharides' efficacy on diabetes mellitus NOD mice

目的 :观察甲壳低聚糖对NOD小鼠糖尿病的治疗效果。方法 :对 12周龄NOD小鼠测血糖值。血糖值高于 11.1mmol L ,有多饮多尿的NOD小鼠为糖尿病NOD鼠 ,随机分成糖尿病治疗组和糖尿病对照组。治疗组用 4 %甲壳低聚糖作饮用水 ,对照组用冷开水作饮用水 ,连续 15周 ,定期测血糖值。期间对治疗显效组随机让 8只鼠饮用一定时间低聚糖后 ,改饮冷开水 ,定期测血糖值 ,观察反弹现象。结果 :治疗组有 6 5 %降血糖作用显著 ,35 %降血糖有效 ;显效组NOD鼠如停饮甲壳低聚糖 ,血糖反弹上升 ;对照组NOD鼠陆续死亡。结论

Objective: To investigate the treating effects of chitooligosaccharides on diabetes NOD mice. Methods: the Nod mice were measured the blood glucose. These mice whose blood glucose were greater than 11.1mmol/L an drank much water and had much urine were divided into two groups: diabetes treating group and diabetes control group randomly. The control groups and the treating groups received cool water or 4% chitooligosaccharides as drinking water for 15 weeks respectively. Then these mice were measure the blood glucose at the given time. At this span, to investigate the rebound phenomena, taking 8 mice received cool water randomly when they had received 4%chitooligosaccharides a period of time and measured their blood glucose at the given time. Results: In the treating group, there were 65% mice who had the marked effect on decreasing blood glucose and 35% mice who had the availability effect on decreasing blood glucose. If the mice stop drinking chitooligosaccharides, their blood glucose were rebounded. The mice of control group died in succession. Conclusion: It was indicated that chitooligosaccharides not only have the treating effects on the diabetes NOD mice but also can prolong their life-span.