胃黏膜相关淋巴组织型淋巴瘤临床病理分析

GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) TYPE LYMPHOMA:A CLINICOPATHOLOGICAL STUDY

目的 :研究胃黏膜相关淋巴组织 (MAL T)型淋巴瘤的形态特征。方法 :应用 HE染色及免疫组化 Eivison二步法观察胃 MAL T型淋巴瘤。结果 :17例胃 MAL T型淋巴瘤为 B细胞表达 ,Kappa(+) 6例 ,L ambda(+) 8例。瘤细胞以 CCL细胞型为主 ,淋巴上皮病变 13例 ,滤泡克隆化 8例 ,反应性滤泡增生 11例。结论 :淋巴上皮病变、滤泡克隆化、反应性滤泡增生及 B细胞单克隆性是胃MAL T型淋巴瘤的主要特征 ,有别于胃良性病变引起的淋巴组织反应性增生。

Objective:To study the morphological characteristics of gastric MALT type lymphoma.Methods:Both hematoxylin-eosin staining and immunohistochemistry (EnVision two-step method) were applied to observe gastric MALT lymphoma.Results:17 cases of gastric MALT lymphoma expressed B cell with 6 kappa positive and 8 lambda positive,and mainly centrocyte-like cell type. In addition, 13 cases were lymphoepithelial lesions, 8 follicular cloning and 11 reactive follicular hyperplasia.Conclusion:Lymphoepithelial lesion, follicular cloning reactive follicular hyperplasia and monoclonal B cell were the principal characteristics of gastric MALT lymphoma, all of which are distinct from those reactive hyperplasia in lymphoid tissue resulting from gastric benign lesions.