p53蛋白在子宫颈癌组织中表达的临床意义

THE CLINCAL SIGNIFICANCE OF p53 PROTEIN EXPRESSION IN UTERINE CERVIX CARCINOMA

目的 :探讨 p5 3蛋白在子宫颈癌组织中表达的临床意义。方法 :用鼠抗人 p5 3单克隆抗体 ,以 SP免疫组化法检测 p5 3蛋白。结果 :p5 3蛋白阳性表达率为 5 6 .3 % ,其表达与肿瘤大小、TNM分期、有无淋巴结转移无关 (P>0 .0 5 ) ,与肿瘤分化程度有关 (P<0 .0 1)。 p5 3蛋白阳性与阴性组比较 ,其术后生存率差异有显著性 (P<0 .0 1)。结论 :子宫颈癌组织中 p5 3蛋白表达与肿瘤大小、TNM分期及有无淋巴结转移无关 ,与肿瘤分化程度密切相关 ,并可用于判断预后。

Objective:To study the expression of p53 protein and its clinical significance in uterine cervix carcinoma.Methods:To investigate p53 protein expression with mouse anti-human p53 monoclonal antibody by SP immunohistochemical method.Results:The positive rate of p53 protein expression was 56.3 %. Its expression had no statistical correlation with tumor length, TNM stage or lymph node metastasis (P>0.05), but had obviously statistical correlation with the degree of tumor differentiation (P<0.01). The survival rate after operation was obviously different between positive and negative expression of p53 protein (P<0.01).Conclusion:The expression of p53 protein in uterine cervix carcinoma had no obvious correlation with tumor size, TNM stage and lymph node metastasis, but had obvious correlation with tumor differentiation. It may be used in evaluating prognosis of uterine cervix carcinoma.