头孢三嗪在结直肠手术中预防感染的应用研究

THE STUDY OF PROPHYLAXIS ADMINISTRATION OF CEFTRIAXONE IN COLORECTAL SURGERY

目的 :探讨头孢三嗪预防结直肠手术后感染的药代动力学依据。方法 :选择 12例结直肠癌患者 ,在麻醉诱导期单剂量静脉滴注头孢三嗪 2 g,给药后在 0 .5 h和 3 h分别取动脉血、腹部脂肪和腹直肌适量 ,并取结肠和肿瘤组织标本 ,用微生物法测定药物浓度。结果 :不同时间各部位药物浓度 :动脉血分别为 (2 30 .6 7± 36 .6 9)μg/ m L和 (132 .72± 18.84)μg/ m L ;腹壁脂肪分别为 (13.80± 3.5 8)μg/ g和 (7.87± 4.77)μg/ g;腹直肌分别为 (10 .6 8± 5 .0 1)μg/ g和 (7.14± 3.86 )μg/ g;结肠和肿瘤分别为 (2 9.0 9± 6 .78)μg/ g和 (2 2 .6 3± 11.0 8)μg/ g。结论 :麻醉诱导期单剂量静脉滴注头孢三嗪 2 g,在手术期间可提供有效的血液和组织药物浓度。

Objective:To search for a pharmacokinetic gist of ceftriaxone (CTRX) in the prevention of infections after colorectal surgery.Methods:12 cases of colorectal cancer patients were injected with single-dose CTRX 2 g intravenously during the induction of anaesthesia. Microbiological method was used to monitor the CTRX concentrations in the arterial bloods, abdominal fat tissues, abdominal muscles, colorectal tissues and tumour tissues at 0.5 and 3 hours after ceftriaxone administration.Results:Arterial blood CTRX concentrations were: (230.67±36.69) g/mL and (132.72±18.84) g/mL; abdominal fat tissues were: (13.80±3.58) μg/g and (7.87±4.77) μg/g;abdominal muscles were: (10.68±5.01) μg/g and (7.14±3.86) μg/g;colorectal and tumour tissues were: (29.09±6.78) μg/g and (22.63±11.08) μg/g.Conclusion:Single-dose ceftriaxone 2 g is injected intravenously during the induction of anaesthesia and can supply efficacious drug concentrations in patients blood and tissues.