BRCA1和基因组稳定性

BRCA1 and Genomic Stability

BRCA1基因编码一个220kDa的多功能区核蛋白,能与癌基因蛋白(c-myc、E2F等)、抑癌基因蛋白(p53、RB、BRCA2)、DNA修复相关蛋白(RAD50、RAD51)、细胞周期调节蛋白(cyclinsandCDKs)以及转录调节因子(RNApolymeraseⅡ)等多种重要蛋白相互作用,不仅能抑制细胞生长,还参与细胞周期调控、基因转录调节、DNA损伤修复以及凋亡等多种细胞活动,在维持基因组稳定性中起重要作用。本文对BRCA1的生化结构及其在维持基因组稳定性中的作用做一综述。

BRCA1 is a 220kDa nuclear protein with multiple functional domains. It interacts directly or indirectly with a variety of important proteins, including oncogene proteins (c myc, E2F), tumor suppressor proteins (p53, RB, BRCA2), DNA damage repair proteins (RAD50, RAD51), cell cycle regulators (cyclin, CDK), transcriptional regulators (RNA polymerase Ⅱ) and others related to the important biological events. BRCA1 is likely to play an important role in the maintenance of genomic stability through its activities in cell cycle progression, DNA damage repair, transcriptional regulation, and apoptosis. Here, the authors provided a review of the biochemistry structure of BRCA1 as well as its role in maintaining the genomic stability.