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血清CA19-9水平与胰腺癌转移及手术切除率关系的初步探讨 被引量:13

THE RELATIONSHIP BETWEEN SERUM CA19-9 LEVEL AND METASTASIS AND RESECTION RATE OF PANCREATIC CARCINOMA
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摘要 目的 探讨血清 CA19- 9水平与胰腺癌病程的关系。方法 测定 5 0例病理检查确诊的胰腺癌血清 CA19- 9水平 ,分析 CA19- 9水平与胰腺癌有无远处转移、血管侵犯及手术切除率的关系。结果 高血清 CA19- 9水平 (>2 0 0 U/ ml)组合并远处转移率 (14例 ,5 6 % )明显高于低血清 CA19- 9水平组 (5例 ,2 0 % ) (P<0 .0 1) ,而合并血管受侵率 (14例 ,5 6 % )与低血清 CA19- 9水平组 (9例 ,36 % )相比差异不大 (P>0 .0 5 )。高血清 CA19- 9水平组患者的根治性肿瘤切除率 (3例 ,12 % )明显低于低血清 CA19- 9水平组 (11例 ,4 4 % ) (P<0 .0 1)。结论 血清 CA19- Objective To study the relationship between serum CA19 9 level and metastasis rate,resection rate of pancreatic carcinoma.Methods 50 patients with pancreatic carcinoma were divided into high serum CA19 9 level (>200 U/ml) group and hypo serum CA19 9 level (≤200 U/ml) group.The relationships between serum CA19 9 level and metastasis rate,resective rate of pancreatic carcinoma were analysed.Results Compared with 25 patients with hypo serum CA19-9 level (≤200 U/ml) group,metastasis rate or pancreatic carcinoma is higher significantly (14/5 cases,P<0.01),and resective rate is lower significantly(3/11 cases, P<0.01) in 25 patients with high serum CA19 9 level (>200 U/ml)group.Conclusion Serum CA19 9 level may be of important value in predicton of metastasis of pancreatic carcinoma.
出处 《肝胆外科杂志》 2003年第1期27-29,共3页 Journal of Hepatobiliary Surgery
关键词 胰腺癌 CA19-9 转移 手术切除 Pancreatic carcinoma CA19 9 Metastasis
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参考文献6

  • 1Forkmark CE,Lambiase L,Vogel SB.Diagnosis of pancreatic cancer and prediction of unresecrability using the tumor-associated antigen CA 19-9[].Pancreas.1994
  • 2Satake K.A clinical evaluation of carbohydrate antigen 19-9(CA19-9) and carcinoembronic antigen ( CEA) in patients with pancreatic carcinoma[].Journal of Surgical Oncology.1985
  • 3Steinberg W.The clinical utility of the CA19-9 tumor-associated antigen[].The American journal of Gastroenterology.1990
  • 4Lillem oe K D.Current management of pancreatic carcinoma[].Annals of Surgery.1995
  • 5Steinberg WM,Gelfand R,Anderson KK.Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas[].Gastroenterology.1986
  • 6Schmiegel WH,Kreiker C,Eberl W,et al.Monoclonal antibidy defines CA19-9 in pancreatic juices and sera[].Gut.1985

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