摘要
目的 探讨肝缺血再灌注对肝硬化鼠胃粘膜的病理损伤过程。方法 实验大鼠制备肝硬化模型 ,并行肝脏缺血再灌注 ,取大鼠胃粘膜标本行电镜、光镜检查 ,并检测血中转氨酶的变化。结果 肝硬化鼠胃粘膜出现充血、水肿 ,有糜烂及小溃疡形成 ,电镜见内质网扩张、线粒体肿胀 ;肝缺血再灌注后病理过程较前加重 ,表现为溃疡面的扩大 ,部分出现粘膜上皮脱落等 ,细胞崩解 ,内质网扩张明显 ,核膜不清。
Objective To study the pathomorphological change in gastric mucosa after liver ischemia reperfusion in cirrhotic rats.Methods 140 liver cirrhosis rats was prepared.Ischemia reperfusion was performed in each group.Pathological change was studied by light and transmission electronic microscopy.Blood ALT AST was detected.Results Gastric mucosa show edema congestion in cirrhotic rats,erosion and small ulcers was also observed.Morphology on transmission electronic microscopc manifested dilatation of SER and mitochondrion,pathological procedure aggravated after IR.Conclusion Pathomorphological procedure in PHG rats was aggravated after IR.
出处
《肝胆外科杂志》
2003年第1期70-71,共2页
Journal of Hepatobiliary Surgery
关键词
肝硬化
肝缺血再灌注
胃粘膜
损伤
Liver cirrhosis
Ischemia reperfusion
Gastric mucosa injury
