CD_(25)单克隆抗体治疗皮质激素耐药的重度移植物抗宿主病

Treatment of severe steroid-refractory graft-versus-host disease with IL-2R α chain (CD_(25)) monoclonal antibody

目的 观察白细胞介素 (IL) 2受体α链 (CD2 5)单克隆抗体治疗激素耐药重度移植物抗宿主病 (GVHD)的疗效。方法 对异基因造血干细胞移植后诊断皮质激素耐药重度GVHD体 17例患者 ( 18例次 ) ,在诊断确立后第 1、4( 3)、8、15、2 2天将CD2 5人源化单克隆抗体 (赛尼派 ) 5 0mg溶于 10 0ml生理盐水中静脉点滴治疗。观察治疗后GVHD缓解情况 ,副作用以及合并感染情况。结果 ( 1) 18例次中 11例GVHD完全缓解 ,5例GVHD部分缓解 ,2例无效。 ( 2 ) 7例出现感染。 ( 3)完全缓解 11例患者中GVHD复发 4例。 ( 4)无输注相关毒副作用。结论 IL 2受体α链 (CD2 5)单克隆抗体治疗重度皮质激素耐药GVHD疗效显著。

Objective To investigate the effects of IL-2R α chain (CD 25) monoclonal antibody on severe steroid-refractory graft-versus-host disease (GVHD). Methods Seventeen patients (18 times) with severe steroid-refractory GVHD were treated with intravenous drip of humanized CD 25 monoclonal antibody on day 1, 3 or 4, 8, 15 and 22. The cumulative scoring of GVHD and status of infection were observed, and laboratory tests, including blood counting and blood biochemical test were made before and 1, 4, 8, 15, 22, 29, 36, 43 and 50 days after the treatment. Results (1) Eleven of the eighteen case-times (61.1%) got complete relief, five (27.8%) GVHD got partial relief, and two (11.1%) failed to get relief. (2) Seven case-times (33.3%) had infection. (3) Relapse of GVHD occurred in four of the eleven case-times with complete relief (36.4%). (4) No infusion-related reaction was observed. Conclusion The monoclonal antibody against IL-2 receptor α chain (CD 25) has a marked effect upon severe steroid-refractory GVHD.