血管性痴呆患者事件相关电位P300及相关因素研究

Study of event-related potential P300 and the relative factors in patients with vascular dementia

目的 :研究血管性痴呆患者的事件相关电位P30 0及相关因素诊断的应用。方法 :对 4 2例VD和 36例无痴呆脑梗死患者进行听觉P30 0检测 ,并进行病因、病变部位等危险因素对比分析。结果 :VD组常有高血压、糖尿病、震颤麻痹、皮质下病灶、多发性病灶、双侧半球病灶及脑萎缩 ,并有 2次以上卒中发生。VD组N1、P2、N2、和P3潜伏期均明显延长 ,P2、P3波幅分别降低 ,与对照组比较差异有显著意义 (P <0 0 1)。结论 :高血压、糖尿病、震颤麻痹 ,反复卒中、皮质病灶、多发性病灶、脑萎缩均是VD的危险因素 ,与VD的发生、发展有关。事件相关电位P30 0是一种客观的神经电生理学指标 。

Objective:To study the event-related potentials P300 and the relative factors in patients with vascular dementia.Methods:The event-related potential P300 was determined in 42 patients with vascular dementia and 36 cerebral infarction patients without dementia.The risk factors such as the cause of disease,the focal site,etc.were analyzed comparatively.Results:The VD group often have hypertension diabetes mellitus,paralysis agitans,subcortex focus,multifocus and bilateral hemisphere focus,as well as cerebral atrophy,the VD patients often suffered stroke for more than two times,the latentcy of N1,P2,N2 and P3 in VD group was prolonged,and the amplitude of P2 and P3 decreased.A significant difference was noted as compared with the control group.Conclusions:Hypertension,diabetes mellitus,paralysis agitans,recurrent cerebral stroke subcortex focus,multifocus,bilateral hemisphere focus and brain atrophy might be the risk factors of VD.They might be related to the occurring and developing of VD.The event-related potentials P300 might be an objective electroneurophysilogical index.It might be of pratical value in the early diagnosis of vascular disease.