辛芩冲剂治疗变应性鼻炎的疗效和安全性分析

A clinical observation on the therapeutic effect of Xinqin granule on allergic rhinitis

目的探讨辛芩冲剂对变直性鼻炎的疗效和安全性。方法 确诊为变应性鼻炎的患者142例随机分成两组,试验组(112例)接受辛芩冲剂口服,一次5g,一日3次;对照组(30例)接受千柏鼻炎片口服,一次3片,一日3次,二种药物均用药20天。观察的症状包括喷嚏、流涕、鼻塞和鼻痒,并进行4分法评分,计算出治疗后积分改善率。结果经过20天的治疗,辛芩冲剂治疗组的临床控制率为27.67％(31/112),显效率为43.75％(49/112),有效率为1 7.86％(20/112),无效率为10.71％(12/112),总有效率为89.29％(100/112);千柏鼻炎片治疗组的临床控制率为0％(0/30),显效率为6.67％(2/30),有效率为20.00％(6/30),无效率为73.33％(22/30),总有效率为26.67％(8/30)。经统计学处理两者差异有显著性意义(P<0.01),辛芩冲剂治疗组明显优于千柏鼻炎片治疗组,辛芩冲剂和千柏鼻炎片治疗组的病人均未发生不良反应。结论辛芩冲剂具有疗效好、无毒副作用等优点,是治疗变应性鼻炎的理想药物。

Objective To observe the therapeutic effect of Xinqin granule(XQG) on allergic rhinitis (AR). Methods 142 cases with AR were randomly divided into two groups, with 112 cases in treating group and 30 cases in controlling group. Then, XQG was given to the pa tients in treating group, 5g each time and 3 times a clay, while Qianbai rhinitis tablet (QRT) was given to those in controlling group, 3 tablets each time and 3 times a day, all being treated for 20 days. During the course of treatment, all symptoms were observed and evaluated based on a standard scoring system. Results By the end of therapy, the clinically cured, significantly effective, effective and total effective rates wrere 27. 67% (31/112) , 43.75% ( 49/112 ), 17.86 (20/112 ), 10. 71%(12/112)and 89. 29% (100/112) for treating group and O, 6. 67% (2/30) , 20. 00%(6/ 30) ,73. 33%(22/'30)and 26. 67%(8/30)for controlling group respectively, with a significant difference between the two groups and no significant side effects among all the cases observed in treating group. Conclusion XQG is significantly effective on AR, with no toxic and side effects, and can be safely used in clinic.