乙肝病毒X蛋白结合蛋白在肿瘤发生发展中的作用

Roles of hepatitis B X-interacting protein in tumor development

乙肝病毒X蛋白结合蛋白(hepatitis B X-interacting protein, HBXIP)最早因其能够与乙肝病毒X蛋白结合而被命名. HBXIP能够通过影响肿瘤细胞增殖、迁移、侵袭、血管生成、细胞凋亡、代谢和免疫逃逸等过程,参与癌基因表达调控及细胞内多种信号途径,在肿瘤的发生发展中扮演非常重要的角色.本课题组多年来围绕HBXIP在肿瘤中的作用和机制进行了大量研究工作.本文针对HBXIP在肿瘤发生发展中发挥的作用及其分子机制进行综述.

Hepatitis B X-interacting protein(HBXIP)was named for its interaction with the hepatitis B virus X protein.HBXIP can affect cell proliferation,migration,invasion,angiogenesis,apoptosis,metabolism,and immune escape,it is involved in the regulation of oncogene expression and multiple cell signaling pathways,playing critical role in tumorigenesis and development.For several years,our group has conducted research on the role and mechanism of HBXIP in cancer.This review summarizes the various roles of HBXIP in tumor development and associated molecular mechanisms.