摘要
传统的miRNA-靶基因-生物学功能研究思路忽略了靶基因之间、靶基因所在信号通路之间的联系,使得miRNA调控作用的整体性与关联性无法得到全面的阐释。运用整体、系统且联系的思维方式,通过对荧光素酶报告实验验证的miR-205靶基因及其信号通路的整理和分析,将明确miR-205的研究方向,并为突破现有miRNA研究的整体格局,探索新颖的miRNA调控机制提供帮助。
Traditional research ideas of miRNA-target gene-biological function have ignored the contact between the target genes and signaling pathways involved,making the integrity and relevance of miRNA regulatory mechanisms not be fully elucidated. Integrated with systematic and relevant way of thinking,summarization and analysis for the luciferase reporter assay validated miR-205 target genes and their related signaling pathways will pave the way for new research area for miR-205,and,it will be helpful for breaking through the status quo and exploring the novel research areas for miRNA.
出处
《基础医学与临床》
CSCD
2015年第1期112-116,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(30860319
81160248
81360313)
江西省研究生创新专项资金(YC2013-S006)
