NLRP3炎性小体研究进展

Research advances in NLRP3 inflammasome

炎性小体是一种多蛋白复合体,它能够识别多种病原微生物及应激相关内源性信号分子,在固有免疫中发挥重要作用。炎性小体可通过活化半胱氨酸天冬氨酸酶-1(caspase-1)诱导促炎因子IL-1β和IL-18的成熟、释放,引起炎性反应,参与多种疾病如家族性周期性自身炎性反应、缺血再灌注损伤和动脉粥样硬化等的发生发展过程。

Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress-associated endogenous molecules and play an important role in innate immune system. Inflammasomes cause inflammation response by inducing maturation of inflammatory cytokines interleukin( IL)-1β and IL-18 through activation of caspase-1,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome,ischemia-reperfusion injury and atherosclerosis.