循环5-羟色胺对胆汁酸稳态的影响

Effect of serum 5-hydroxytryptamine on the homeostasis of bile acid

5-羟色胺(5-HT)是人体重要的神经递质和胃肠激素,中枢神经系统和外周循环中的5-HT分属于完全独立的系统,循环5-HT主要来源于肠道。循环5-HT对肝脏胆酸合成酶及外排转运体具有调控作用,并可通过调控回肠及肾脏胆酸转运体影响胆酸的肠-肝循环及肾排泄,说明外周5-HT对胆汁酸稳态具有调控作用。研究并阐明5-HT对胆酸稳态的影响及机制,可为胆汁酸紊乱性疾病的发病机制研究提供线索,并为其治疗靶点的发现提供依据。

5-Hydroxytryptamine is an important neurotransmitter and gastrointestinal hormone in the body. There are two independent 5-hydroxytryptamine systems, one in the central nervous system and one in the periphery one. Peripheral 5-hydroxytryptamine of serum mainly comes from gastrointestinal tract. Regulatory effect of serum 5-hydroxytryptamine on hepatic bile acids synthesis and efflux transport have been identified, and also the effect on bile acids transporters in ileum and kidney, which resulted in the bile acids alteration in enterohepatic circulation and renal excretion, indicating the important role of serum 5-hydroxytryptamine on the homeostasis of bile acids. To investigate and clarify the effect and underlying mechanism of serum 5-hydroxytryptamine on the homeostasis of bile acids will provide clues for the pathogenesis discovery of bile acids disorder-related diseases, and also provide evidences for the therapeutic strategy development.