环状RNA在白血病发生与发展中的研究进展

Research progress of circular RNA in tumorigenesis and development of leukemia

环状RNA(circRNA)是一种独特的内源性非编码RNA。大多数circRNA在生物体内是保守的并且经常显示在组织发育阶段特异性的表达。环状RNA在肿瘤的发生和发展调控中起到关键性的作用。因此,circRNA作为研究消化系统、妇科等肿瘤疾病的热点之一,发现其可以作为新的肿瘤标志物以及可能成为临床治疗的新靶点。

Circular RNA(circRNA) is a unique endogenous non-coding RNA. Most circRNAs are conserved within the organism and often show specific expression at the stage of tissue development. Circular RNA plays a key role in the regulation of tumorigenesis and tumor development. Therefore, circRNA is one of the hot spots of research on digestive system, gynecological and other cancer diseases, and it is believed that it can be used as a new tumor marker and may become a new target for clinical treatment.