组织工程化肌腱植入体内的研究进展

The Related Research of Tissue-engineered Tendon in Vivo

组织工程化肌腱修复肌腱韧带缺损及功能重建是目前的研究热点。所选用的支架材料不仅要对人体无毒副作用 ,还要求其易于细胞黏附 ,能诱导胶原沉积 ,新腱形成 ,并具有接近正常肌腱的力学性能。近年的研究发现 ,随着支架材料在体内的降解及其腱化 ,植入的组织工程化肌腱的力学性能也有所改变。胶原生成。

Using tissue-engineered tendons to repair tendons and ligaments as well as functional reconstruction is the focus of nowadays researches. The scaffolds must be not only unharmful to health, but also easy for cells attachment, and be able to induce collagen deposition to form a neotendon with mechanic properties similar to those of normal tendon. In recent researches, it has been found that the mechanic properties of the implants change with the degrading and femdonizing of scaffolds. The relationships between collagen deposition, scaffolds degradation and mechanic properties of neotendon need to be defined more clearly.