卵巢上皮性肿瘤间质微血管密度与临床病理因素的关系

Relationship between microvessel density of ovarian epithelial tumor and clinical pathological factors

目的 检测卵巢上皮性肿瘤中间质微血管密度 (MVD)的表达情况 ,分析其与肿瘤生物学行为的关系。方法 应用免疫组织化学的方法 ,选用ⅧRAg染色 ,对 64例 (2 2例良性、9例交界性、3 3例恶性 )卵巢上皮性肿瘤石蜡组织切片中MVD进行检测 ;并将其结果与几项临床病理因素进行相关分析。结果 MVD在 40 0×视野下 ,良性组、交界性组、恶性组三者之间均有显著性差异 (P良 ,交界 <0 .0 5 ;P良 ,恶 <0 .0 1;P交界 ,恶 <0 .0 5 )。MVD与腹水量呈正相关性 (r =0 .3 5 8,P <0 .0 1)。MVD与肿瘤大小无相关性。良性组中 ,MVD在粘液性肿瘤中显著高于浆液性肿瘤 (P <0 .0 5 ) ;恶性组中 ,MVD在浆液性和粘液性肿瘤中表达无显著性差异 (P >0 .0 5 )。结论 MVD反映了组织内血管生成的状态 ,随着组织分化程度的降低而升高 。

Objectives To investigate the expression of microvessel density (MVD) in ovarian epithelial tumor(OET), and to determine the relationship between MVD and clinical and pathological factors.Methods VIII Rag was used to detect microvessels of the samples from 64 patients with OET (22 benign tumor, 9 borderline tumor, 33 malignant tumor) by immunohistochemical staining.Results MVD increased while the grades of histological differentiation decreased, and there were significant differences among the benign, the borderline and the malignant tumor(P<0.05). There was positive correlation between ascites and MVD(r=0.358, P<0.05) and negative correlation between the tumor size and MVD. In benign OET, MVD of mucous tumor was significantly higher than that in serous tumor(P<0.05), but there was no difference between mucous and serous tumors in malignant OET.Conclusions MVD reflets the state of angiogenesis in tumor, and with the grades of histological differentiation decreasing, MVD increases, which would be helpful to judge the types of tumor.