卡维地洛对冠心病心力衰竭患者心室重构和心功能的影响

Effects of carvedilol therapy on the left ventricular remodeling and cardial function in patients with coronary heart disease with cardiac dysfunction

目的 探讨卡维地洛对冠心病心力衰竭患者心室重构及心功能的影响。方法 冠心病心力衰竭患者 80例 ,左室射血分数≤ 45 % ,心功能Ⅱ～Ⅲ级 ,常规治疗基础上随机分为治疗组和对照组 ,治疗 6个月 ,观察卡维地洛对心室重构、心功能的影响。结果 经过 6个月治疗 ,与对照组相比 ,卡维地洛组左室射血分数明显升高 (P <0 .0 1) ,左室收缩末容量指数、左室舒张末容量指数、左室重量指数均显著降低 (P <0 .0 1)。结论 在常规治疗的基础上 ,应用卡维地洛能显著改善冠心病心力衰竭患者的心功能 。

Objective To investingate the effect of carvedilol on cardiac function and ventricular remodeling in patients with coronary heart diseases(CHD) and cardiac dysfunction.Methods In 80 CHD patirnts with cardiac dysfunction, the left ejection fraction of them was ≤45% and cardial function was grade Ⅲ. On a basic of routine therapy,they were divided randomly into observational group and control group for a follow-up period of 6-month.The ventricular function and left remodeling were measured by echocardiography Results The left ventricular ejection fraction was increased significantly(P<0.01), and the left ventricular end-systolic volume index, the left ventricular end-diastolic volume index and the left ventricular mass index were decreased in carvedilol group campared with those in control group after 6 months(P<0.05 and P<0.01, respectively).Conclusin The routine treatment plus carvedilol therapy can improve left ventricular functions and ventricular remodeling in CHD patient with heart failure.