梗阻性黄疸患者血清中IGF-Ⅰ的变化与免疫功能

The variations of serum IGF-Ⅰin patients with obstructive jaundice and the patients' immunological function

目的 探讨和研究IGF -Ⅰ对梗阻性黄疸免疫功能影响。方法 收集 2 0例梗阻性黄疸病人的临床资料 ,并对患者血清的ALT、γ -GT、Endotoxin、IGF -Ⅰ、SIL - 2R、T淋巴细胞亚群、免疫球蛋白等进行检验。结果 良性梗阻性黄疸与对照组相比 ,IGF -Ⅰ水平显著降低 (P <0 .0 1) ,而SIL - 2R则显著升高 (P <0 .0 1) ;在胆道梗阻解除后 ,IGF -Ⅰ显著上升 ,SIL - 2R则显著下降 (P <0 .0 1)。在良性梗阻性黄疸时 ,血清中的IGF -Ⅰ浓度的变化与SIL - 2R的浓度变化呈负相关 (r =0 .72 3,P =0 .0 2 8)。结论 IGF

Objective To study the changes of serum IGF-Ⅰ in patients with obstructive jaundice the relationship between IGF-Ⅰ and patients' immunological function. Methods The clinical data of 20 patients with obstructive jaundice were collected and serum ALT, γ-GT, SIL-2R, Endotoxin, Immunoglobulins, T-lymphocyte subgroups and IGF-Ⅰ were measured patients with cholecystolithiasis were used as control. Results The serum IGF-Ⅰ in patients with obstructive jaundice was significantly lower than that in control group (P<0.01). After the biliary duct obstruction was removed, the serum concentration of IGF-Ⅰ was significantly higher than that before operation and the serum concentration of SIL-2R was significantly lower than that before operation. The serum IGF-Ⅰ is negatively related to SIL-2R patients with benign obstructive jaundice (r= 0.728, P=0.028). Conclusions The results show that IGF-Ⅰ plays an important role in the changes of immunological function of patients with obstructive jaundice.