NPC与MPV方案治疗晚期非小细胞肺癌的疗效比较

Retrospective Comparison between NCP and MPV Protocls for Advanced Non-small Cell Lung Cancer

目的 :比较NPC与MPV方案治疗晚期非小细胞肺癌 (NSCLC)的疗效。方法 :6 4例晚期NSCLC患者采用NPC32例 ,采用Kaplan -Meier方法分析患者生存期。采用Cox比例风险模型分析影响预后的因素。结果 :MPV组中位生存期为 8个月 ,NPC组中位生存期 12个月。两组生存期差异有显著性 (P <0 0 0 5、 0 0 0 1)化疗的毒副反应主要是胃肠道反应和骨髓抑制。结论 :NPC比MPV能延长患者生存期 。

Objective:To compare the theapeutic effects between NCP and MPV protocols for advanced non-small cell lung cancer(NSCLC).Methods:Sixty-four patieuts havin advanced non-small cell lung cancer,the NPC and MPV Kaplan Meier meehods,were adopted to studdy 32 patients in eachs respectively for the survival rate and the cox regression prognostic factors.Results:The overall median two-years survival time in the MPV group was 8 months,and 12 months in the NPC group.The major toxic effects of the two groups were gastrointerstinal tract reactions and myelosuppression.Conclusion:NPC chemotherapy can prolong the survival time more in patients with advanced NSCLC than MPV chemotherapy but without increasing its toxicity.