盐酸氟桂利嗪治疗脑出血并发脑水肿疗效分析

THE EFFECTIVENESS OF ET-1 AND NSE OF SIBELIUM IN SECONDARY CEREBRAL EDEMA OF HEMORRHAGE

目的 探讨盐酸氟桂利嗪治疗脑出血并发脑水肿的疗效及作用机制。方法 90例脑出血患者随机分为盐酸氟桂利嗪治疗 (观察 )组 50例 ,常规治疗组 40例。常规治疗组进行常规治疗 ,观察组在常规治疗的基础上给予盐酸氟桂利嗪 5mg ,每晚口服 ,共 2 0d ,并分别在治疗前、治疗后 3d、1周进行病情评分及内皮素 - 1 (ET - 1 )、神经元特异性烯醇化酶 (NSE)测定 ,并与常规治疗组进行对比。结果 ①观察组的临床疗效优于常规治疗组 ,差异有显著性 (P <0 .0 5) ;②盐酸氟桂利嗪治疗后ET - 1、NSE浓度明显低于治疗前 ,差异有高度显著性 (P <0 .0 1 ) ,随着病程的延长 ,二者血浆含量有下降趋势 ,与脑水肿的严重程度密切相关。结论 ①盐酸氟桂利嗪治疗脑出血并发脑水肿具有肯定疗效 ;②ET - 1、NSE血浆浓度测定可能成为脑出血并发脑水肿诊断及疗效评估的客观指标。

Objective To study the therapentic effective and mechanism of sibelium in secondary cerebral edema of hemorrhage. Methods 90 cases with hemorrhage are randomly divided into Sibelium treatment group of 50 cases and routine treatment group of 40 cases .The patients of Sibelium group are given routine treatment+Sibelium 5mg oral every night 20 days on end. The two groups are conducted condition evaluation and measurement of plasma concentration of ET-1,NSE,being compared with contrast group. Results ① The clinical effectiveness of Sibelium group is superior to that of routine treating group.②The plasma concentration of ET-1,NSE after treatment of Sibrlium is lower than that before treatment(P<0.01) and decreases to the normal level basically, having no significantly difference compared with contrast group(P>0.05 ). Routine group has no significantly difference before and after treatment,and is higher than contrast group obviously after treatment. The concentration level of ET-1?NSE is relevant to the severity degree of cerebral edema. Conclusion ① Sibelium has positive therapentic effective when hemorrhage.② Sibelium can intervene with the concentration of ET-1?NSE.Their concentration measurement can become the objective experimental criteria of diagnosis and effectiveness evaluation of secondary cerebral edema of hemorrhage.