文拉法辛治疗继发于生活事件的抑郁症的疗效分析

Effective and safe analysis of venlafaxine on the treatment for depression induced by life events

目的探讨文拉法辛治疗继发于明显生活事件的抑郁症的效果。方法对58例最近1年内生活事件量表(LES)总分>30分的抑郁症患者采用文拉法辛治疗6w。结果治疗结束时Hamilton抑郁量表(HAMD)总分自22.36±4.18下降至9.86±5.76。Hamilton焦虑量表(HAMA)总分自23.24±5.14下降至10.36±6.42。HAMO迟滞因子睡眠因子和临床疗效总评分也显著下降。第1周即显著有效。不良反应轻微。结论文拉法辛可有效治疗继发于明显生活事件的抑郁症患者,起效快,不良反应小。

objectives: To examine venlafaxine's effective and safe characters as a treatment for depression induced by life events.Methods: 58 depressed patients with the total scores of life events scale(LES) in a year >30 were treated by venlafaxine for six weeks.Results: At the endpoint,the mean total scores of hamilton depression scale(HAMD) dropped to 9.86±5.76 from 22.36±4.18 at baseline,and hamilton anxiety scale(HAMA) went down to 10.36±6.42 from 23.24±5.14.The scores of the hysteresis factor and sleeping factor in HAMD and Clinical Global Impressions-Improvement showed significantly decreased.The patients got significantly improvement in one week.The adverse events were few and mild.Conclusion: Venlafaxine is effective for depression induced by severe life events,the effect response come quickly,adverse events are mild.