中药复方“通脉口服液”治疗慢性肾炎气虚血瘀证的临床研究

Clinical investigation on chronic glomerulonephritis by tongmai oral solution

目的观察通脉口服液对慢性肾炎气虚血瘀证患者血清肾纤三项及症状、体征的影响。方法60例中医辨证为气虚血瘀的慢性肾炎患者随机分为治疗组和对照组各30例。治疗组采用常规西医降压、抗凝、降脂等对症治疗;治疗组在常规西医治疗的基础上加用通脉口服液,治疗3个月后测定两组患者血清肾纤三项指标,观察其临床症状的改善程度。结果两组均可在一定程度上降低肾纤三项的水平,改善临床症状和体征。两组相比较,治疗组作用更为明显,且差异有显著性(P<0.05)。结论通脉口服液可有效地减轻慢性肾炎气虚血瘀证患者肾纤维化的程度。

Objective:To observe the curative effect of tongmai oral solution on the chronic glomerulonephritis patients which syndrome differentiation of TCM was belong to deficiency of qi and blood stasis.Methods:The clinic study with comparison,randomized control was taken.60 patients was randomly divided into treat group and contrast group.There were no significant difference between the two groups in sex,age,degree of diseases and laboratory indexs.The two groups also were taken the therapeutic measures such as depressurization,anticoagulation and symptomatic treatment.and the tong,ai oral solution was added in the treat group.The course of treatment was 8 weeks.Serum III precollagen,IV collagen and laminin level and clinical symptoms were measured.Results:In a certain extent,the patients'clinic symptoms and the index of kidney fibrous were ameliorated in two groups after 3 months,and the effect of treat group was more predominance than the contrast group.Conclusion:Tongmai oral solution can lessen the degree of kidney fibrous of the chronic glomerulonephritis patients which syndrome differentiation of TCM was belong to deficiency of qi and blood stasis.