利维爱治疗围绝经期综合症的临床观察

Clinical observation of Livial on the treatment of perimenopause syndrome

目的研究利维爱治疗围绝经期综合症的临床效果。方法将160例围绝经期综合症患者平均分为两组,观察组为服用利维爱1.25～2.5 mg,1次/d,对照组为服用尼尔雌醇1～2 mg,1次/15 d,观察两组用药前后更年期症状、情绪、泌尿生殖道症状及治疗效果等的改善情况。结果分别对用药后3个月潮热、出汗、情绪、阴道干燥、性交困难等均有不同程度的改善。观察组用药后3个月后显效58例(72.5%);有效例21例(26.25%);无效1例(1.25%)。对照组用药3个月后,显效50例(62.5%);有效18例(22.5%);无效12例(15%)。结论利维爱治疗围绝经期综合症的临床效果显著,在缓解围绝经期症状方面效果优于尼尔雌醇,不良反应少于尼尔雌醇。

Objective: To explore the curative effect of Livial on perimenopause syndrome.Methods: 160 patients with perimenopause syndrome were divided into two groups,the observation group were treated with 1.25～2.5mg Livial per day,and the control group with 1～2mg nilestriol at interval of 15 days.The climac-teric symptom,the emotional disorder,the urogenital tract symptom and the therapeutic effects were ob-served before and after treatment.Results: Many symptoms such as hot,sweating,the emotional disorder,colpoxerosis and dyspareunia were all improved during 3 months following treatment,there were 58 cases with marked effect(72.5%),21 cases with effective(26.25%),and 1 case with no-effect(1.25%) in the obser-vation group.In the control group cured 50 patients(62.5%),effectual 18 patients(22.5%)and ineffective 12 cases(15%).Conclusion: Livial is more effective than nilestriol for perimenopause syndrome.