妊娠期高血压疾病患者血清PECAM-1、sVEGFR-1的临床意义

The clinical significances of serum PECAM-1 and sVEGFR-1 levels of women with hypertensive disorder complicating pregnancy

目的:探讨妊娠期高血压疾病患者血清血小板内皮细胞黏附分子-1(PECAM-1)、人可溶性血管内皮生长因子受体1(sVEGFR-1)水平变化及临床意义。方法:收集2017年2月—2018年2月本院收治的36例妊娠期高血压孕妇、58例子痫前期患者以及34例正常妊娠孕妇,比较各组间血清PECAM-1和sVEGFR-1表达水平差异。结果:正常孕妇、妊娠高血压、轻度子痫前期以及重度子痫前期组孕妇PECAM-1表达水平逐渐降低,sVEGFR-1水平逐渐升高,且重度子痫前期组两项指标与另外3组存在差异(P<0.05)。多因素回归分析,PECAM-1、sVEGFR-1是导致妊娠期高血压疾病的独立危险因素(P<0.05)。结论:PECAM-1和sVEGFR-1可作为妊娠期产妇是否发生妊娠期高血压的重要参数指标,值得临床关注。

Objective:To investigate the changes of serum platelet endothelial cell adhesion molecule-1(PECAM-1)and soluble vascular endothelial growth factor receptor-1(sVEGFR-1)of women with hypertensive disorder complicating pregnancy(HDCP),and to study their clinical significances.Methods:From February 2017 to February 2018,36 pregnant women with HDCP were randomly selected in group A,58 pregnant women with preeclampsia were randomly selected in group B,and 34 normal pregnant women were randomly selected in group C.The serum PECAM-1 and sVEGFR-1 levels of women were compared among the three groups.Results:The PECAM-1 expression of women in group C was highest,and that of women in group B was lowest.The sVEGFR-1 expression of women in group C was lowest,and that of women in group B was highest.The levels of PECAM-1 sVEGFR-1 and sVEGFR-1 of women in group B had significant different than those of women in group A and C(P<0.05).The multivariate regression analysis had showed that PECAM-1 level and sVEGFR-1 level were independent risk factors for HDCP(P<0.05).Conclusion:The levels of PECAM-1 and sVEGFR-1 can be used as important parameters for HDCP,which is worthy of clinical attention.