维生素D在复发性流产中的免疫作用机制与研究进展

The research progress and mechanism of Vitamin D in recurrent miscarriage

复发性流产(RM)在育龄妇女中的发病率为1%～3%。正常妊娠的维持需要母体对胎儿产生免疫耐受,而免疫耐受机制被破坏且未得到及时治疗,将引起RM。维生素D(VD)已被证明在调节母体-胎儿免疫平衡中发挥重要作用,可促进母体对胎儿发生免疫耐受,维持正常妊娠,已有研究表明,VD含量与RM密切相关。本文就VD在维持妊娠过程中的作用机制及其目前在RM中的研究进展进行综述,为临床治疗因VD缺乏或不足引起的RM奠定基础。

Recurrent miscarriage(RM)refers to a spontaneous abortion that occurs over 2 times before 20 gestational weeks,and its incidence in women of childbearing age is about 1%to 3%.Maintenance of normal pregnancy requires the mother to develop immune tolerance to the fetus.If the immune tolerance mechanism is destroyed and not treated promptly,it will cause RM.Vitamin D(VitD)has been shown to play an important role in regulating immune balance between mother and fetus,promoting maternal immune tolerance to the fetus,and maintaining normal pregnancy.Studies have shown that VitD level is closely related to RM.This article reviews the mechanism of VitD for maintenance of pregnancy and its current research progress in order to providing evidence for clinical treatment of RM caused by lack or deficiency of VitD.